European Pain School®

at the University of Siena

European Pain School®

at the University of Siena

EPS 2025 • Cancer Pain

Siena | Italy • 7-13 June 2025

Cancer Pain

Siena | Italy • 7-13 June 2025

Programme

Ln Faculty Lectures (L1-L16)
Sn Scholars’ Oral Presentations (S1-S23)
Wn Interactive Workshops, Seminars and Special Presentations (W1-W2)

  • Saturday, 7 June

    Arrival of Scholars and Faculty at the Certosa di Pontignano and accommodations
    15:00-17:00 Guided tour of Certosa by Giancarlo Carli
    17:00-17:30 Welcome greetings by Anna Maria Aloisi
    17:30-18:30 Opening lecture L1. Sebastiano Mercadante (Palermo, Italy)
    Cancer pain: from basic to specialized approach
    20:00 Dinner
  • Sunday, 8 June

    8:00 Breakfast
    9:00-10:00 L2. Sebastiano Mercadante (Palermo, Italy)
    The difficult cancer pain
    10:00-10:20 S1. Müge Altinkök (Stockholm, Sweden)
    Rostral Ventromedial Medulla neurons mediate sleep deprivation-induced pain sensitivity
    10:20-10:40 S2. Ayşe Bağcı (Ankara, Turkey)
    The impact of premedication and analgesia management on postoperative pain and anxiety: A prospective study supported by regional anesthesia
    10:40-11:00 Coffee break
    11:00-11:20 S3. Ana Maria Boaventura de Oliveira (São Paulo, Brazil)
    Apitoxin and melittin promote long lasting analgesia and delay the pain onset in a model of chronic neuropathy
    11:20-11:40 S4. Rosamaria Caminiti (Catanzaro, Italy)
    Exploring the role of bergamot polyphenols in alleviating morphine-induced hyperalgesia and tolerance through modulation of mitochondrial SIRT3
    11:40-12:40 L3. Francesco De Logu (Florence, Italy)
    Schwann cell Piezo1 mediates pain in cancer perineural invasion
    13:00-15:00 Lunch
    15:00-16:00 L4. Brian L. Schmidt (New York, NY, USA)
    The role of proteases in cancer pain
    16:00-16:20 S5. Edward Ciputra (Copenhagen, Denmark)
    Identifying novel targets for the treatment of bone pain in multiple myeloma
    16:20-17:00 Coffee break
    17:00-17:20 S6. James Cottam (Baltimore, MD, USA)
    Modelling and predicting placebo effects among pain-free and chronic pain participants: a machine learning approach
    17:20-18:20 L5. Brian L. Schmidt (New York, NY, USA)
    Recapitulation of human cancer pain in preclinical models
    20:00 Dinner
  • Monday, 9 June

    8:00 Breakfast
    9:00-10:00 L6. Nigel W. Bunnett
    Receptor Tyrosine Kinases: mediators and therapeutic targets for cancer and pain
    10:00-10:20 S7. Ronessa Dass (Ridgeway, ON, Canada)
    Brain fog in persons with chronic pain
    10:20-10:40 S8. Troy Dildine (Palo Alto, CA, USA)
    Predicting high impact chronic pain diagnosis using psychological and sociocultural patient characteristics
    10:40-11:00 Coffee break
    11:00-11:20 S9. Sofia Fontana-Giusti (Reading, United Kingdom)
    Activation of autophagy by the tat-beclin 1 peptide reveals a protective mechanism in chemotherapy-induced neuropathic pain
    11:20-11:40 S10. Chuang Ge (New York, NY, USA)
    Extracellular matrix regulation of glial plasticity in mice
    11:40-12:40 L7. Francesco De Logu (Florence, Italy)
    Glial cells intracellular signaling in Cancer pain
    13:00-15:00 Lunch
    15:00-16:00 L8. Nigel W. Bunnett
    The contribution of endocytosis to signaling of cancer pain
    16:00-16:20 S11. Alexandros Guekos (Zurich, Switzerland)
    Healthy women show more experimentally induced central sensitization compared with men
    16:20-17:00 Coffee break
    17:00-17:20 S12. Gabrielle Herbillon (Brussels, Belgium)
    Modulating spinal and cortical activity with hypnosis: can hypnotic hypoesthesia modulate early somatosensory evoked potentials?
    17:20-18:20 L9. Ofrit Bar-Bachar (Ramat Yishai, Israel)
    QST: from small fiber to central pain processing
    18:20-19:10 W1. Workshop: Technical demonstration
    Ofrit Bar-Bachar (Ramat Yishai, Israel)
    19:10-20:00 W2. Workshop: Technical demonstration
    Ofrit Bar-Bachar (Ramat Yishai, Israel)
    20:00 Dinner
  • Tuesday, 10 June

    8:00 Breakfast
    9:00-10:00 L10. Lesley Colvin (Dundee, United Kingdom)
    Chemotherapy-induced painful neuropathy – where are we now?
    10:00-10:20 S13. Humay Ismayilzada (Ankara, Turkey)
    Retrospective evaluation of demographic and clinical features in malignancy-related pain
    10:20-10:40 S14. Matilde Marini (Florence, Italy)
    Anti-nociceptive action of Leonurine through TRPA1 and TRPV4 modulation
    10:40-11:00 Coffee break
    11:00-11:20 S15. Valeria Mazza (Catanzaro, Italy)
    SIRT1: a likely key for future therapeutic strategies for pain management
    11:20-11:40 S16. Constanza Miguel (Pilar, Argentina)
    Sex differences in oxaliplatin-induced peripheral neuropathy and persistent pain: effects of natural polyphenol resveratrol administration
    11:40-12:40 L11. Lesley Colvin (Dundee, United Kingdom)
    Improving translation in chemotherapy induced painful neuropathy
    13:00-15:00 Lunch
    15:00 Wineyard Tour
    20:00 Dinner
  • Wednesday, 11 June

    8:00 Breakfast
    9:00-10:00 L12. Irina Vetter (Brisbane, Australia)
    Animal models of chemotherapy-induced neuropathy: improving translational relevance
    10:00-10:20 S17. Yatendra Mulpuri (New York, NY, USA)
    TRPV4 activation in Schwann cells mediates mechanosensitivity in oral cancer pain
    10:20-10:40 S18. Tu Nguyen (New York, NY, USA)
    TRPV4 receptor on Schwann cell contributed to oral cancer pain
    10:40-11:00 Coffee break
    11:00-11:20 S19. Sofia Passaponti (Siena, Italy)
    Extracellular vesicles and ZFHX2: insights into nociception and novel pathways for pain modulation
    11:20-11:40 S20. Sahil Patel (London, United Kingdom)
    Development of a novel gene therapy for neuropathic pain
    11:40-12:40 L13. Irina Vetter (Brisbane, Australia)
    Neuro-immune mechanisms of chemotherapy-induced neuropathy: insights from animal models
    13:00-15:00 Lunch
    15:00-16:00 L14. Luana Colloca (Baltimore, MD, USA)
    Pain modulation through virtual reality: from mechanisms to clinical trials
    16:00-16:20 S21. Alice Pifferi (Siena, Italy)
    Expression and modulation of CYP450 enzymes in neuroblastoma cells: possible implications for pain management
    16:20-17:00 Coffee break
    17:00-17:20 S22. Sonali Shrivastava (Durg, India)
    Prevalence of pain in women health care workers
    17:20-18:20 L15. Luana Colloca (Baltimore, MD, USA)
    Placebo effects: mechanisms and predictors
    20:00 Dinner
  • Thursday, 12 June

    8:00 Breakfast
    9:00-10:00 L16. Carlo Bellieni (Siena, Italy)
    The holistic pain treatment and the Achille's complex
    10:00-10:20 S23. Hla Sudan (Siena, Italy)
    Role of Exosomes derived from intestinal cells in the pathogenesis of neurodegenerative diseases
    10:20-10:40 Coffee break
    11:00 Closing remarks
    13:00-15:00 Lunch
    15:00 Siena Tour
    20:00 Farewell dinner
  • Friday, 13 June

    Departures